03230fam a2200241 a 4500020002600000082001400026100002100040245003700061250001400098260006600112300002500178500002000203505088900223520034501112520027301457520046101730520000602191520018102197520049202378520007902870650002202949700001702971  a0751401269 (acidfree)00a547.2 NOR1 aNorman, R. O. C.10aPrinciples of organic synthesis.  a3rd ed. /  aLondon ;aNew York :bBlackie Academic & Professional,c1993.  axv, 811 p. :bill. ;  aIncludes index.2 a1. Chemical thermodynamics -- 2. Molecular structure -- 3. Chemical kinetics -- 4. Mechanism -- 5. Stereochemistry -- 6. Formation of carbon-carbon bonds: organometallic reagents -- 7. Formation of aliphatic carbon-carbon bonds: base-catalyzed reactions -- 8. Formation of aliphatic carbon-carbon bonds: acid-catalyzed reactions -- 9. Pericyclic reactions -- 10. Formation of aliphatic carbon-nitrogen bonds -- 11. Electrophilic aromatic substitution -- 12. Nucleophilic aromatic substitution -- 13. Aromatic diazonium salts -- 14. Molecular rearrangements -- 15. Reagents containing phosphorus, sulfur, silicon or boron -- 16. Photochemical reactions -- 17. Free-radical reactions -- 18. Organotransition metal reagents -- 19. Oxidation -- 20. Reduction -- 21. The synthesis of five- and six-membered heterocyclic compounds -- 22. The syntheses of some naturally occurring compounds.  aThe purpose of this book is to show how mechanistic principles can be applied both to acquiring a knowledge of organic synthetic processes and to planning the construction of organic compounds. It is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject.8 aThe book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself, and stereochemistry.8 aIn Part II, these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds: for example, how small molecules can be built on to give larger ones by the construction of new carbon-carbon bonds, or how one functional group can be transformed into another. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex naturally occurring compounds8 a.8 aThere have been numerous important developments since the second edition of this book was published 15 years ago, and every chapter has been brought up to date to include them.8 aAmong the more notable are: the stereochemical control of reactions, reflecting the need to synthesize efficiently compounds with several asymmetric centres; the use of organotransition-metal reagents, leading to a new chapter; the exploitation of lithium diisopropylamide (LDA) as a base in the formation of new C-C bonds; free-radical reactions for the synthesis of C-C bonds; uses of organosilicon compounds; and subtle new protective and condensing reagents in polypeptide synthesis.8 aThe text is extensively cross-referenced and a detailed index is included. 0aOrganic compounds1 aCoxon, J. M.